Three cats are described with plasmacytic pododermatitis of multiple footpads, and with a swelling of the nose resulting in a 'Shar pei nose' appearance. A diagnosis of 'ectopic plasmacytic pododermatitis' was confirmed in two cats by histopathologic examination. The histologic diagnosis of the nasal swelling in the third cat, which was FIV positive, was demodicosis. These cases are interesting because of their clinical presentation, the unexpected differential diagnosis, and because of their excellent response to treatment.