In 1996 and 1997 a new epizootic enteric rabbit disease appeared in Europe. Since then the disease has also been reported in other parts of the world. Its main symptoms are caused by paresis of the intestinal tract. The causative agent is still unknown. The disease has been reported in meat rabbits and does, as well as in pet rabbits. The present report concerns a naturally occurring case of this disease in a specific-pathogen-free (SPF) rabbit colony. In the intestinal contents of one animal sacrificed for thorough examination, rotavirus and an apathogenic type of Escherichia coli were detected. From the ileal wall Providencia rettgeri was isolated, which is unlikely, however, to be of pathogenic significance. Histological and electron-microscopical analyses did not reveal any pathognomonic lesions.