Titel:
Granulaire lymfocytaire leukemie bij een hond
Auteur(s):
H. DE BOSSCHERE, S. VANDERSCHUEREN, K. BRUYLAND
Samenvatting:
The present case study describes a 14-year-old female intact Staffordshire with large granular lymphocytic (LGL) leukemia with an aggressive clinical course. This is a rare lymphoproliferative disorder that is unique due to the morphology of the neoplastic lymphocytes, which are characterized by the presence of large round to irregularly shaped azurophilic cytoplasmic granules. The diagnosis was made on the basis of a combination of clinical signs (lethargy, anorexia, vomiting and diarrhea), routine hematology (anemia, thrombocytopenia, and circulatory neoplastic cells), cytology, histopathology (involvement of liver, spleen and bone marrow) and immunophenotyping. Neoplastic lymphocytes were characterized as T-cells likely expressing the gamma/delta receptor. This condition closely resembles hepatosplenic lymphoma in humans.