Title:
Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium
Author(s):
T. ERKENS, S. DAMINET, C. ROGIERS, K. GOMMEREN, E. LAMPO, D. VANDER DONCKT, A. VAN DEN BROEKE, M. VAN POUCKE, A. VAN ZEVEREN, L.J. PEELMAN
Abstract:
Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-basepair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein. Thereis no information available, however, regarding the presence of this mutation in dogs in Belgium. In this study,the ABCB1 genotype was assessed in 92 dogs of breeds suspected to possess the deletion mutation. The resultsindicated that the mutation was present in the Australian Shepherd, Collie, Shetland Sheepdog and SwissWhite Shepherd, but was not detected in the Bearded Collies, Border Collies and German Shepherds of thisstudy, which is in accordance with the findings in similar breed populations of other countries. In Belgium itis therefore important to take the ABCB1 genotype of the breeds involved into account, in order to use drugsin a safe and efficient manner and to improve the selection procedure in dog breeding.