The objective of this study was to find the most significant parameters to identify horses withlarval cyathostominosis, caused by infection with small strongyles. A retrospective study with 307horses, that were presented at the Faculty of Veterinary Medicine (Ghent University) between 2008and 2018, was performed. Horses older than three months with diarrhea, of which feces was examinedat the Faculty of Veterinary Medicine, were included in this study. The definitive diagnosis of larvalcyathostominosis was determined by the presence of L4/L5 larvae in the feces. Clinical examinations,blood and fecal analyses were performed in all cases and compared to determine positive predictivevalues for larval cyathostominosis. Blood albumin concentration appeared to be the most significantvalue. Albumin concentrations less than 20 g/L had the highest significance (<0.004) to predict apositive fecal sample. The combination of an albumin concentration less than 20 g/L, sex (female),body temperature (>38.2°C), neutrophilia (>67%) and season (October-March) was the most accurate(72%) in predicting the presence of larval cyathostominosis. Due to the moderate significance of thismodel, fecal examination remains essential to confirm larval cyathostominosis suspicion.