In this paper, necrotizing eosinophilic dermatitis with an acute onset and a rapidly progressiveclinical course is reported in three dogs. Early skin lesions were characterized by intensely pruritic,erythematous and firm intact papules and plaques. The lesions enlarged and evolved quickly intocoalescing nodular target shaped lesions with central exudation, ulceration and necrosis. Thelesion distribution pattern was mainly the neck and the dorsolateral trunk. Oral involvementwas observed in one dog. The histopathology was characterized by eosinophilic dermatitis andpanniculitis targeting dermal and subcutaneous blood vessels with secondary involvement ofhair follicles. While causation remained unproven in these cases, a hypersensitivity reaction tomedications or other foreign antigens was suspected.