In this article, the use of desoxycorticosterone pivalate is retrospectively reviewed in eightdogs with primary hypoadrenocorticism, presented at the Small Animal Department of GhentUniversity. The results showed that desoxycorticosterone pivalate provided adequate mineralocorticoidreplacement in all cases, also in the dogs that had previously been treated with fludrocortisoneacetate. A starting dosage of 1.5 – 2.2 mg/kg SC was used, with a fixed dosing interval of28 days in most of the cases. Each time, prednisolone was added to the therapy as glucocorticoidsupplementation. No side effects related to desoxycorticosterone pivalate therapy were notedand all owners were satisfied with the treatment consisting of desoxycorticosterone pivalate andprednisolone.