Distal sesamoidean ligament (DSL) injury is a recognized cause of lameness in horses. Thepurpose of this study was to describe the contrast-enhanced computer tomography (CE-CT)findings in horses with injury to the DSL compared to a control group without injury to the DSL.Medical records of horses referred for CE-CT between 2008 and 2015 were reviewed. Cases wereselected retrospectively based on a CE-CT imaging finding of injury to the DSL. Three horseshad DSL injury as the only finding, while the remaining horses had one or more concomitant injuries.DSL injury and fetlock trauma and/or suspensory branch desmitis were the most frequentinjury combinations. CE-CT can be of value in diagnosing DSL injury. The high number of concurrentDSL and fetlock and/or suspensory lesions suggests that further investigation should beconsidered when evaluating horses with injuries related to either of these structures.