To the authors’ knowledge, this is the first report, in which a simultaneous occurrence ofSalmonella-associated multifocal osteomyelitis and intra-abdominal abscessation in a foalpresenting with weight loss, diarrhea and fever is described. No evidence of failure of passiveimmune transfer had been present at birth. Radiographic examination revealed multifocal type Posteomyelitis. Bacterial culture of synovial fluid revealed a Salmonella spp. Antibiotic treatmentwas adjusted based on the sensitivity results; however without clinical improvement. The foaldeveloped abscess formations within the left femoral region, and finally a Salter Harris type Ifracture of the left femur. Euthanasia was elected based on this finding. Post-mortem computedtomography revealed a large mass within the caudal abdomen that extended into the left pelvicand hind limb region, as well as multifocal osteomyelitis.Pathological examination identified the mass as a large abscess with multiple fistula tracts.Salmonella spp. was additionally cultured post mortem.