Melanocytic tumors are commonly encountered neoplasms in horses. In this case report, an atypicalcase of a melanocytoma in an almost five-year-old Andalusian horse is described. Histopathologicalexamination showed a striking epidermal component consisting of multifocal to miliary nests ofepitheloid cells, which were spread discontinuously in all layers of the epidermis, including the outerroot sheath of the hair follicles. This phenomenon is called pagetoid spreading or buckshot pattern andis a feature of multiple human neoplasms, among which are melanomas, Paget disease and Bowen’sdisease. To the authors’ knowledge, this is the first case report to describe pagetoid spreading in anequine melanocytic tumor.