86 (3) pp 136

Title: 
Pathophysiology of lipopolysaccharide-induced inflammatory response in birds
Author(s): 
R. HOUBEN, S. CROUBELS, A. WATTEYN, G. ANTONISSEN
Abstract: 

Inflammation is a protective response to infection and/or tissue damage and it induces migration ofimmune cells and mediators of immune response from the circulation to the infected and/or damagedtissue. This response will remove the initial noxe (e.g. lipopolysaccharide or LPS) and tissue healing willbe stimulated. LPS is part of the outer membrane of gram-negative bacteria and causes an inflammatoryresponse in birds due to its proinflammatory properties. As a result to this inflammatory response,birds develop a change in body temperature, increased production of proinflammatory cytokines andacute phase proteins, show leukocytosis and sickness behavior. The magnitude of these symptomsin birds depends on the bird species and differs from the symptoms in mammals. The characteristicsand pathophysiology of an inflammatory response are frequently studied using LPS inflammationmodels. These models can further be applied for pharmacodynamic studies to assess the clinical effectof different anti-inflammatory drugs, such as non-steroidal anti-inflammatory drugs or NSAIDs. In thispaper, an overview of the LPS-induced inflammatory response in birds is given.

Full text: 
pp 136-147
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