Meningoencephalitis of unknown etiology (MUE) is a frequently diagnosed and often fataldisease in veterinary neurology. The aim of this retrospective study was to assess the efficacy ofthree different sole prednisolone treatment schedules in dogs diagnosed with MUE. The dogswere diagnosed clinically with MUE based on previously described inclusion criteria, and treatedwith a three-, eight- or eighteen-week-tapering prednisolone schedule. Thirty eight dogs were includedin the study. Seventeen, fifteen and six dogs received the three-, eight- and eighteen-weektapering schedule, respectively. Overall, 37% of the dogs died or were euthanized because ofMUE, and a significant difference in survival time was seen between the three treatment schedules.Surprisingly, the highest number of dogs that died because of MUE was seen in the eightweektreatment schedule (56%), followed by the three-week (26%) and eighteen-week (0%)treatment schedule. Based on the results of this study, no definitive conclusions can be drawnregarding the ideal prednisolone dosing protocol for dogs diagnosed with MUE. However, a moreaggressive and immunosuppressive treatment protocol might lead to a better outcome.