Tumors of the pigment cells or chromatophores in reptiles are classified as melanophoromas,iridophoromas, xanthophoromas, erythrophoromas or mixed type chromatophoromas based on thepredominant type of pigment, and constitute a relatively common neoplastic disorder in captivereptiles. Especially melanophoromas and iridophoromas are frequently observed. The diagnosis ofchromatophoromas is usually made through histological examination. The use of immunohistochemistryor electron microscopy may be required to discriminate the different types of chromatophoromas.Whenever possible, complete surgical excision is the treatment of choice. Due to the distinct malignancyand tendency to metastasize, the prognosis of cutaneous chromatophoromas in reptiles is generallyguarded. Consequently, an early and correct diagnosis of these neoplastic disorders in reptiles is vital.This article provides an overview of the current knowledge regarding the occurrence, the performance,the pathogenesis and the diagnostic and therapeutic approach of chromatophoromas in reptiles withemphasis on melano- and iridophoromas.