85 (6) pp 335-342

Title: 
The efficacy of chloroquine treatment of Giardia duodenalis infection in calves
Author(s): 
M. GULTEKIN, K. URAL, N. AYSUL, A. AYAN, C. BALIKCI, G. AKYILDIZ
Abstract: 

The purpose of the present study was to evaluate the effect of chloroquine treatment on cystexcretion in calves naturally infected with Giardia duodenalis. The calves were randomly assignedinto two groups based on placebo (group I, n=7 untreated control calves) or treatment (groupII, n=7 calves treated orally with 2.5 mg/kg chloroquine twice daily for five consecutive days).The G. duodenalis isolates were identified by molecular characterization with β-giardin nestedPCR and gene sequence analysis as assemblage A3. Cyst excretion was determined on days 0, 3,7 and 10, before and after treatment. Geometric means of the number of excreted cysts did notchange significantly in the control group during the trial. The reduction in cyst excretion afterchloroquine treatment was 99% on day 3 and 100% on days 7 and 10. Chloroquine treatment ismost probatly practically applicable, relatively inexpensive and highly effective against giardiosisin calves.

Full text: 
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