85 (4) pg 197

Title: 
Feminization and severe pancytopenia caused by testicular neoplasia in a cryptorchid dog
Author(s): 
D. PAEPE, L. HEBBELINCK, A. KITSHOFF, S. VANDENABEELE
Abstract: 

In this case report, a paraneoplastic syndrome caused by testicular neoplasia in a ten-year-oldcryptorchid dog is described. Feminization and pancytopenia were observed, resulting from thetesticular neoplastic production of estrogens. A diagnosis of testicular tumor and associated bonemarrow suppression was made by ultrasonography and blood examination, with estrogen bloodlevels being severely elevated. Urinalysis revealed a urinary tract infection. Castration was performedtogether with a blood transfusion, and antibiotic treatment was started. After an initialimprovement, the dog died suddenly after approximately three weeks.In this report, the importance is highlighted of identifying clinical signs associated with feminizationin intact male dogs at an early stage, to avoid severe, potentially irreversible, hematologicalconsequences due to bone marrow suppression. Elective orchidectomy of both testes ishighly recommended in cryptorchid dogs as neoplastic transformation of the undescended testismay occur, with potentially fatal outcome.

Full text: 
pp 197-205
Case report(s)