A ten-year-old European Shorthair cat was presented with complaints of progressively worseningdyspnea with open-mouth breathing and inspiratory and expiratory stridor. Histopathologicalexamination of a biopsy, collected during tracheoscopy, revealed that the mass was an intraluminaltracheal adenocarcinoma. Computed tomography (CT) revealed no metastases and the excision of thetumor was performed during the same anesthesia. Intravenous premedication was not possible due tothe behavior of the patient and induction of anesthesia was provided using intramuscular injection ofalfaxalone. The maintenance of anesthesia was initially provided by inhalation of isoflurane vaporizedin oxygen using a laryngeal mask and a circle rebreathing system, followed by total intravenousanesthesia (TIVA) with alfaxalone during the actual excision of the tumor. By removal of seventracheal rings, the tumor could be completely removed.