85 (2) pg 94

Title: 
Oral ivermectin intoxication on a veal farm
Author(s): 
H. VERMEULEN, B. PARDON, S.CROUBELS, J. VERCRUYSSE, P. DEPREZ
Abstract: 

In this case report, a presumably deliberate oral ivermectin intoxication is described on a veal farm,in the first week after arrival of the calves. All 330 calves, aged between two and four weeks, showedsevere depression, sternal to lateral recumbency, tremor and headshaking. Of the calves, 13.6% died.The remaining animals gradually recovered within five to seven days with supportive oral rehydrationtherapy. The source of intoxication was the milk replacer with an ivermectin concentration of 35 mg/kg. The serum of three affected calves contained ivermectin between 0.75 mg/kg and 1.1 mg/kg. Thesuspected oral dose of ivermectin was 1.75 mg/kg bodyweight for an average calf (40 kg). This reportdemonstrates that signs of oral ivermectin intoxication may occur in calves of two to four weeks of ageat a dose 8.75 times the registered therapeutic dose for subcutaneous administration in cattle.

Full text: 
pp 094-099
Case report(s)