Psoroptic mange, caused by Psoroptes ovis, is a problem on many Flemish farms where Belgianblue beef cattle are bred. Two intensive treatment schedules were evaluated on nine Belgian blue farmswith a persistent mange problem. On farms 1 to 7, all animals were treated twice (with a seven-to-tendaysinterval) with an injectable macrocyclic lactone (ML), while on the two remaining farms, theinitial treatment consisted of one injection with the long acting (LA) formulation of moxidectin (10%).Skin scrapings were taken after treatment, and when living mites were found on at least one animal,all animals (farms 1 to 7) or only positive animals (farms 8 and 9) were treated consecutively with aninjectable ML. On all farms, the treated animals were clinically healthy and P. ovis free at the end ofwinter, after two to nine treatment rounds (two injections with a seven to ten-days interval or one LAinjection). Although mange reappeared on the first seven farms after the subsequent grazing season, thedisease was less severe and easier to control.