In this case report, a markedly painful ulcerative dermatitis consistent with pyodermagranulosum is reported in a 2.5-year-old entire female Maltese dog. The dog had a nasal stridorand irregular ulcers with raised inflammatory borders involving the lumbar area, tail and thehindlimbs. The lesions did not respond to antibiotics. Histopathologic features include deepcrateriform ulcerations with massive infiltrations of neutrophils beneath and adjacent to theulcers. Treatment with prednisolone (Kela Laboratories, Sint-Niklaas, Belgium) alone resultedin the resolution of nasal signs and all skin lesions.