A two-month-old German shepherd dog was presented with anorexia, lethargy and left hindlimb lameness associated with swelling of the thigh. Clinical findings combined with cytology ledto the presumptive diagnosis of necrotizing fasciitis (NF). Extensive debridement was performedand silver-foam-based negative pressure wound therapy (NPWT) was applied. During the first48 hours, a negative pressure of -75 mmHg was used. Evaluation of the wound demonstrated noprogression of necrosis and a moderate amount of granulation tissue formation. A new dressingwas placed and a second 48-hour cycle of NPWT was initiated at -125 mmHg. At removal, ahealthy wound bed was observed and surgical closure was performed.The prompt implementation of NPWT following surgical debridement led to acceleratedwound healing without progression of necrosis in this case of canine NF. Negative pressure woundtherapy could become an integral part of the management strategy of canine NF, improving theprognosis of this life-threatening disease.