Postpartum dysgalactia syndrome (PDS) is an economically important condition in sows. Thesyndrome is characterized by a reduced milk and colostrum production within 12 to 48 hourspost partum. The objective of this study was to determine whether preventive treatment withketoprofen (Ketofen®10%, Merial, Belgium) has a positive effect on the subclinical form of PDS.Sows (n = 39) were randomly divided into two groups: one served as control group whereas theother was treated intramuscularly with ketoprofen within twelve hours after parturition.During the first 24 hours postpartum, the rectal temperature of the sows decreased (-0.43 ±0.13 °C) in the ketoprofen group. In the control group, an increase was seen (+0.07 ± 0.02 °C)(P < 0.05). There was no significant effect on back fat loss of the sows, weight gain of the piglets(n = 541) and survival rate.In conclusion, a single intramuscular administration of ketoprofen to sows shortly afterfarrowing decreased rectal temperature but did not improve the performance of the piglets.