The metacarpo-/metatarsophalangeal joint is a high motion joint and is therefore prone to be injured.Lameness attributable to the metacarpo-/metatarsophalangeal joint is a frequent cause of early retirement fromathletic activity in horses and should therefore be detected as early as possible. The basis of the examination forlameness remains the clinical examination, including a complete motion examination in which the lameness isunambiguously localized by means of local anesthesia. A combination of radiography and ultrasonography isoften sufficient for visualizing the lesions.However, in the absence of clear radiological or ultrasonographical findings, more advanced imagingmodalities, such as computed tomography (CT) or magnetic resonance imaging (MRI), are necessary. The choiceof technique largely depends on the tissue characteristics of the expected lesion, the cost restraints of the owner,and the willingness to take the risk of general anesthesia.