In contrast to dogs, immune-mediated hemolytic anemia is rarely seen in cats and occurs most oftensecondary to an underlying infectious, neoplastic or inflammatory process. Clinical symptoms are often vagueand are caused by severe anemia and the effect of hypoxia on organ systems. Laboratory abnormalities in catswith IMHA are comparable to those seen in dogs, with the exception of spherocytes, which are difficult toidentify in cats. The diagnosis is based on hemolytic anemia in combination with a positive ‘true’autoagglutination and/or a positive Coombs test. A search for underlying causes should always be performedand, because infections with hemotrophic mycoplasma species are the most important underlying cause forIMHA in cats, a polymerase chain reaction test to detect these bacteria should be carried out. Treatmentconsists of immunosuppressive drugs, providing oxygen-carrying solutions, treating underlying causes andsupportive care. In cats, IMHA carries a better prognosis than in dogs, although relapses are seen in equalfrequency.