Many articles on anesthesia in llamas have been published. Xylazine, combined with ketamine is the mostfrequently used injectable anesthetic protocol and it warrants an effective and reliable anesthesia to perform shortprocedures. The use of other α2-agonists is far less documented in the literature.A study was carried out to evaluate and compare the anesthetic and cardiorespiratory effects of intramuscularmedetomidine-ketamine and dexmedetomidine-ketamine in llamas. The induction of anesthesia, cardiorespiratoryparameters and the recovery time were similar in both groups. However, during recovery, significantly more ataxiawas observed in the llamas that received medetomidine than in the llamas that received dexmedetomidine.