Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare syndrome characterized by chronic intestinal dilationand dysmotility in the absence of mechanical obstruction. A definite diagnosis of CIPO can only bemade after histological examination of intestinal tissues. The present case describes a CIPO in a 2.5-year-oldBernese Mountain dog with a history of recurrent gastro-intestinal complaints suggestive for pseudo-obstruction.Histological lesions of small intestinal samples consisted of severe loss of smooth muscle cells of thetunica muscularis and diffuse infiltration of mononuclear cells. In addition, a hypertrophy of the lamina muscularismucosa of the small intestinal tract was present. On the basis of these findings and the results of immunohistochemistry,a myopathic form of CIPO was diagnosed.