A 3-year-old, male domestic shorthair cat was presented with signs of progressive muscular hypertrophy.A diagnosis of hypertrophic feline muscular dystrophy was made on the basis of the typical clinicalpresentation in cats and on the basis of the results of medical imaging, the electrodiagnostics and the findingson histopathology and immunohistochemistry of muscle biopsies. The cat was initially successfully treatedwith prednisolone. Eight months after presentation, however, the cat was euthanized because of acute renalfailure. To the author’s knowledge, this is the first report of hypertrophic feline muscular dystrophy in adomestic cat in Belgium.