The results of the analysis of equine and bovine blood samples with the automated pocH-100iV DIFF hematologyanalyzer were compared with the results obtained with reference methods or other analyzers (VetABC, Coulter Counter ZF, Coulter LH 750 analyzer). For equine blood and most parameters in bovine bloodgood to excellent correlations between methods and analyzers were obtained. For bovine blood good to poorcorrelations and significant differences were obtained between the pocH-100iV DIFF and other methods oranalyzers mainly for hematocrit and hemoglobin determinations and platelet counts. Overall the pocH-100iVDIFF seems to be a reliable and user-friendly analyzer.