Thirteen multidrug-resistant MRSA strains from infections of hospitalized horses in an equine clinic wereanalyzed. They all were indigestible by SmaI restriction, possessed SCCmec type IV and belonged to spa typet011. One isolate was analyzed by MLST and allotted to ST398. The MRSA clonal lineage ST398-SCCmec IVappears to have a high capability of causing clinical infections in an equine hospital environment.