The use of improved diagnostic techniques has resulted in an increasing demand for effective treatment ofbrain tu mors. In this ar ti cle, the li te ra tu re on the use and re sults of dif fe rent ty pes of the ra pies such as sur ge ry,chemotherapy, radiation therapy, hormonal therapy, immunotherapy and gene therapy are being reviewed.The im por tant role of the blood-brain bar rier in all its as pects is con si de red. Espe ci al ly the ni tro sou re as, theirside ef fects and sur vi val ti mes are re vie wed in de tail. The most suc ces sful stra te gy in brain ne opla sia is mul -ti-modali ty treatment, whe re a combi nation of neurosurge ry, radi ation therapy and che mothe rapy is applied.Multi-modality therapy can be planned ide ally after obtaining a his tologic diagnosis.