Characteristically, cryptosporidiosis in snakes is caused by Cryptosporidium serpentis. This parasite affects the stomach and may cause considerable morbidity and mortality. This report describes an overview of the current literature. After the importance and prevalence of this parasite are demonstrated, the pathogenesis and the related pathology and clinical signs are described. Subsequently, the different diagnostic methods and therapeutic approaches are mentioned, as well as their use in the prevention and control of cryptosporidiosis in snake collections.