An impala (Aepyceros melampus) premedicated with a combination of xylazine, carprofen, methadone and atropine was anesthetized with isoflurane in oxygen for tibial fracture repair in combination with a lumbosacral epidural injection of bupivacaine for additional analgesia and muscle relaxation during surgery. The cardiopulmonary parameters remained within normal ranges, except for an initial hyperventilation. Recovery after 3 hours of anesthesia following administration of atipamezole was fast and uneventful. Subcutaneous administration of carprofen during a period of 5 days assured adequate postoperative analgesia.