Spontaneously occurring hypercortisolism (Cushing’s syndrome) is a term referring to the constellation ofclinical and chemical abnormalities that result from chronic exposure to excessive concentrations of endogenouscortisol. In dogs it is a common endocrine disorder but in cats the disease is rarely observed.The choice of thetherapy to follow is based on the cause of hypercortisolism (pituitary or adrenocortical tumor), as well as on theexperience of the veterinarian. Several therapeutic options are available, including medical therapies andsophisticated surgeries. The most frequently used treatments are discussed below.