CT is an imaging tool with many applications in various clinical disciplines that is becoming increasingly available to the veterinary profession. CT is particularly valuable for the detection and diagnosis of brain diseases associated with mass lesions. The fact that some intracranial lesions may not be visible on CT is probably due to diffuse distribution, attenuation levels similar to those of the surrounding normal tissue, and minimal or absent contrast enhancement. CT is more accurate than conventional radiography in evaluating the localization, extent and characterization of lesions of the nasal cavity, sinuses, orbital, jaws, temporomandibular joints and tympanic bullae. CT appears to be remarkably accurate in revealing the location and extent of nasal diseases and is superior to conventional radiography for detecting middle ear disease. CT is useful in the investigation of spinal lesions in the event of doubtful radiographic and/or myelographic findings, and can be of help in surgical planning. CT is one of the best imaging modalities for the detection and description of masses, malformations and fluid collections in the thoracic cavity and is considered the most sensitive method for the detection of pulmonary metastases. CT of the abdomen gives excellent anatomic images of the organs and vessels, although the availability of ultrasound may have decreased the demand for abdominal studies. Skeletal CT may be helpful in clinical cases in which standard radiography is negative or inconclusive even though there is a high suspicion of pathology. CT has been proven to be superior in the diagnosis of fragmented coronoid process and other affections of the elbow joint.