87 (4) pp 181

Title: 
Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis
Author(s): 
N. VANDER ELST, E. MEYER
Abstract: 

The increase in bacterial drug resistance causes major difficulties in the clinical treatmentof a growing number of bacterial infections worldwide. Consequently, there is an urgent needto develop novel anti-bacterial agents to control these resistant pathogens and to complementthe currently used antibiotics. Mastitis is the most prevalent disease impacting dairy cattle, andtherefore one of the costliest diseases in the global dairy industry. The excessive use of curative aswell as preventive antibiotics in this sector entails a real risk for the emergence of antimicrobialresistance. Moreover, these traditional antimicrobial agents are often ineffective and lead toresidues in the milk, which can affect dairy product consumers. As an alternative therapeuticapproach, bacteriophages and phage-encoded endolysins have been proposed and are currently(re)investigated as potential antibacterial agents against mastitis.

Full text: 
pp 181-186
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