87 (2) pp 86

Title: 
Intratumoral chemotherapy in an integumentary squamous cell carcinoma in a cockatiel (Nymphicus hollandicus)
Author(s): 
N. VAN HECKE, A. MARTEL, A. GARMYN, I. VAN DE MAELE, T. HELLEBUYCK, S. CROUBELS, R. DUCATELLE, G. ANTONISSEN
Abstract: 

An eight-year-old, female cockatiel (Nymphicus hollandicus) was presented with anorexia,lethargy, a mass at the lower side of the wing and discoloration of the feathers. Physical examinationshowed an ulcerated nodular integumentary lesion of approximately 4 cm³ ventromedial on thewing at the side of the propatagium and the humerus. Lateral and ventrodorsal radiographsrevealed only hepatomegaly. After a stabilization period, surgical excision of the tumor wasperformed. Based on histopathological evaluation and bacterial culture of the surgically removedtissue, the lesion was typed as an integumentary squamous cell carcinoma with secondarybacterial infection (Corynebacterium sp). Four weeks postoperative, the tumor had recurred.Chemotherapeutic treatment was started with intratumoral carboplatin (1.5 mg/cm³) once aweek. Because of further tumor growth after the second administration of carboplatin, resectionof the mass was performed before the next infiltration. However, the bird died during anesthesia.Despite increase in tumor size, histopathological and immunohistochemical evaluations showeddegeneration of the tumor with intercellular edema and vacuolization of the tumor cells,presumably resulting from carboplatin administration. More research is needed to investigatethe efficacy and safety of the intratumoral administration of carboplatin as a treatment option inbirds with integumentary squamous cell carcinoma.

Full text: 
pp 086-092
Case report(s)