86 (2) pp 79

Title: 
Serum C-reactive protein concentrations in dogs with idiopathic epilepsy
Author(s): 
E. SEGERS, V. MARTLÉ, S. PIEPERS, L. VAN HAM, S.F.M. BHATTI,
Abstract: 

Inflammatory reactions in dogs are associated with systemic changes in serum, called the acutephase response; changes in the concentration of acute phase proteins in the serum take place.C-reactive protein (CRP) is a positive acute phase protein, which increases during inflammation.The role of inflammation in epilepsy remains unclear. In this study, the inflammatory responsein dogs with idiopathic epilepsy (IE) was investigated. The aims of the study were: 1. to measureserum CRP concentrations in dogs with IE and in healthy dogs, 2. to measure serum CRPconcentrations in dogs with acute cluster seizures and in dogs with isolated seizures and 3. toobserve the evolution of serum CRP concentrations in time after the last seizure. This studyshowed no significant differences in serum CRP concentrations between dogs with IE (7.8 mg/l)and dogs of the control group (8.3 mg/l). Furthermore, the results showed higher mean serumCRP concentrations in dogs with IE exhibiting cluster seizures (11,8 mg/l) than in dogs withisolated seizures (5.7 mg/l). However, these results were not statistically significant (P = 0.077).Finally, no statistically significant decrease in serum CRP concentrations was seen with timeafter the last epileptic seizure in dogs with IE (P = 0.077).

Full text: 
pp 079-083
Original article(s)