85 (4) pg 185

Title: 
Frequency estimation of disease-causing mutations in the Belgian population of some dog breeds - Part 2: retrievers and other breed types
Author(s): 
E. BECKERS, M. VAN POUCKE, L. RONSYN, L. PEELMAN
Abstract: 

A Belgian population of ten breeds with a low to moderately low genetic diversity or whichare relatively popular in Belgium, i.e. Bichon frise, Bloodhound, Bouvier des Flandres, Boxer,Cavalier King Charles spaniel, Irish setter, Papillon, Rottweiler, Golden retriever and Labradorretriever, was genotyped for all potentially relevant disease-causing variants known at thestart of the study. In this way, the frequency was estimated for 26 variants in order to improvebreeding advice. Disorders with a frequency high enough to recommend routine genotyping inbreeding programs are (1) degenerative myelopathy for the Bloodhound, (2) arrhythmogenicright ventricular cardiomyopathy and degenerative myelopathy for Boxers, (3) episodic fallingsyndrome and macrothrombocytopenia for the Cavalier King Charles spaniel, (4) progressiveretinal atrophy rod cone dysplasia 4 for the Irish setter (5) Golden retriever progressive retinalatrophy 1 for the Golden retriever and (6) exercise induced collapse and progressive rod-conedegeneration for the Labrador retriever. To the authors’ knowledge, in this study, the presenceof a causal mutation for a short tail in the Bouvier des Flandres is described for the first time.

Full text: 
pp 185-196
Theme