85 (3) pg 167

Title: 
Pet dog cancer models in search of novel therapeutic alternatives
Author(s): 
E. ABMA, L. CICCHELERO, H. DE ROOSTER, S. DAMINET, N.N. SANDERS
Abstract: 

In cancer research, rodent cancer models are a standard research tool. However, translation ofcancer research data from rodent to man is far from optimal. Hence, it is recommended that the efficacyof novel cancer drugs is confirmed in higher animal species before human trials are initiated. Pet dogswith spontaneous cancer are the perfect candidates in every respect. Dogs share a similar histologic,biologic and genetic cancer background significantly closer than the relationship between rodent andman. Furthermore, the development and interaction between tumor, host and tumor microenvironmentis comparable to those in humans. There are corresponding diagnostic and treatment options availablefor dogs and humans, while the progression of cancer in dogs is fast enough to obtain results within areasonable period of time. Lastly, pet dogs have a broader access to clinical trials than humans, enablingextensive research opportunities. Moreover, the dog also benefits from participation in clinical studies,since these studies offer an additional treatment option, and hence an additional chance of being cured.

Full text: 
pp 167-170
Continuing professional development