69 (5) 341-344

Title: 
APOPTOTIC NEURONS IN A CAT WITH CEREBELLAR ABIOTROPHY
Author(s): 
H. De Bosschere, M. Bos, R. Ducatelle
Abstract: 

Cerebellar abiotrophy is defined as a premature spontaneous progressive loss of neurons. In an 11-months-old cat with cerebellar abiotrophy, clinical symptoms developed progressively after castration. Histologically a loss of Purkinje cells, granular layer cells and demyelination of white matter were observed. Apoptotic neurons were found using the TUNEL technique. In this case the cerebellar abiotrophy was due to apoptosis of neuronal populations. An episode of anoxia/hypoxia of the nervous system during anesthesia may have played a role in the induction of cerebellar apoptosis.

Full text: 
pp 341-344
Case report(s)